Aim To investigate the relationship among helicobacter pylori (Hp) infection with blood lipid level and AIP in patients with high risk of stroke, and to provide new ideas for the treatment of dyslipidemia and atherosclerosis. Methods Three hundred and sevety-one patients with high risk of stroke were screened from 2872 people who were consecutively selected and had health examination from June 2014 to January 2015 in the Department of Medical Center, General Hospital of Wanbei Coal and Electricity Group. Their clinical information was collected. The Hp infection status was detected by the 14C urea breath test and the serum oxidized low density lipoprotein (ox-LDL) levels was determined by enzyme linked immunesorb-ent assay (ELISA). The relationship between Hp infection and total cholesterol (TG), triglyceride (TG), low density lipoprotein (LDLC), high density lipoprotein (HDLC), ox-LDL, AIP were analyzed. Results 155 patients(41.8%, 155/371)were found infected by Hp；the levels of TC, TG, LDLC, ox-LDL and AIP in Hp infection group were significantly higher than those in non HP infection group, the difference was statistically significant (P＜0.05). Multiple linear regression analysis showed that Hp infection was positively correlated with the level of AIP. Conclusion Hp infection may induce the disorder of lipid metabolism in high risk population of cerebral apoplexy, which leads to the increase of AIP level, and promotes the development of atherosclerosis.