Cardiac regeneration is an important approache for treatment of myocardial infarction and recovery of heart function. The key issue to cardiac regeneration is increasing the number of cardiomyocytes. Up-to-date, increasing studies have revealed that the cell resource of regenerated cardiomyocytes mainly involves three aspects:proliferated cardiomyocytes (cardiomyocytes reentering the cell cycle, activating mitosis procedure), direct reprogramming of somatic cell (cells transdifferentiated into cardiomyocytes directly), directional differentiation based on stem cells. Although stirring progress in the above 3 aspects has been gained, there are still many problems to be solved.