It is known that vascular calcification is a regulated ectopic mineral deposition,which is a common characteristic of chronic inflammatory disorders, such as type 2 diabetes mellitus, atherosclerosis, and chronic kidney disease.Vascular calcification is closely related to the morbidity and mortality of cardiovascular diseases. Vascular calcification is as a state of chronic inflammatory disorders, and inflammatory factors may play an important role in the regulation of vascular calcification. As a kind of non-encoding small RNA, microRNA, many studies have confirmed that it can be through the regulation of vascular smooth muscle cell phenotype conversion, calcium and phosphorus homeostasis, local and systemic expression of inflammatory factors to cause the occurrence and development of vascular calcification. Recently, various kinds of microRNA have been found. In this review, the focus will be on the relationship between inflammation and vascular calcification, the role of inflammation-related microRNA in vascular calcification by regulating the expression of inflammatory factors, which will provide novel concept for future studies on mechanisms of vascular calcification, prevention and treatment strategies of vascular calcification in clinic.