2025年4月16日 周三
Home > Archive>Volume 26, Issue 3, 2018 >310-314
PDF HTML XML Export Cite reminder
Progress of metallothionein 2A in cardiovascular and cerebrovascular diseases
CSTR:
[cstr]
Author:
Affiliation:

Department of Cardiovascular Institute, The First Affiliated Hospital of Hainan Medical College, Haikou, Hainan 570102, China)

Clc Number:

R54

  • Article
    • | |
  • Metrics
    • |
  • Reference [33]
    • |
  • Related [20]
    • | | |
  • Comments
    Abstract:

    Recently, some studies have found that metallothionein 2A (MT2A) is an important antioxidant stress molecule. MT2A gene polymorphism is closely related to coronary heart disease and atherosclerosis. MT2A has the effect of reducing cerebral ischemia-reperfusion injury and protecting the myocardium. The effect of MT2A on cardiovascular and cerebrovascular diseases includes inflammation, oxidative stress, apoptosis and endothelial function. This article reviews the relationship between MT2A and cardiovascular, cerebrovascular diseases.

    Reference
    [1] Kayaalti Z, Soylemezoglu T.The polymorphism of core promoter region on metallothionein 2A-metal binding protein in turkish population.Mol Biol Rep, 0,7(1):185-190.
    [2] Vasak M.Advances in metallothionein structure and functions.J Trace Elem Med Biol, 5,9(1):13-17.
    [3] Chen SH, Chen L, Russell DH.Metal-induced conformational changes of human metallothionein-2A:a combined theoretical and experimental study of metal-free and partially metalated intermediates.J Am Chem Soc, 4,6(26):9 499-508.
    [4] Kimura T, Kambe T.The functions of metallothionein and ZIP and ZnT transporters:an overview and perspective.Int J Mol Sci, 6,7(3):336.
    [5] Ma H, Su L, Yue H, et al.HMBOX1 interacts with MT2A to regulate autophagy and apoptosis in vascular endothelial cells.Sci Rep, 5,5:15 121.
    [6] Nielsen AE, Bohr A, Penkowa M.The balance between Life and death of cells:roles of metallothioneins.Biomark Insights, 7,1:99-111.
    [7] Takahashi S.Positive and negative regulators of the metallothionein gene.Mol Med Rep, 5,2(1):795-799.
    [8] Ling XB, Wei HW, Wang J, et al.Mammalian metallothionein-2A and oxidative stress.Int J Mol Sci, 6,7(9).pii:E1483.doi:10.3390/ijms17091483.
    [9] Yang XY, Sun JH, Ke HY, et al.Metallothionein 2A genetic polymorphism and its correlation to coronary heart disease.Eur Rev Med Pharmacol Sci, 4,8(24):3 747-753.
    [10] Giacconi R, Muti E, Malavolta M, et al.The +838 C/G MT2A polymorphism, metals, and the inflammatory/immune response in carotid artery stenosis in elderly people.Mol Med, 7,3(7-8):388-395.
    [11] Giacconi R, Cipriano C, Muti E, et al.Novel -209A/G MT2A polymorphism in old patients with type 2 diabetes and atherosclerosis:relationship with inflammation (IL-6) and zinc.Biogerontology, 5,6(6):407-413.
    [12] Cong W, Niu C, Lv L, et al.Metallothionein prevents age-associated cardiomyopathy via Inhibiting NF-kappaB pathway activation and associated nitrative damage to 2-OGD.Antioxid Redox Sign, 6,5(17):936-952.
    [13] Xue W, Liu Q, Cai L, et al.Stable overexpression of human metallothionein-IIA in a heart-derived cell line confers oxidative protection.Toxicol Lett, 9,8(1):70-76.
    [14] Velic A, Laturnus D, Chhoun J, et al.Diabetic basement membrane thickening does not occur in myocardial capillaries of transgenic mice when metallothionein is overexpressed in cardiac myocytes.Anat Rec (Hoboken), 3,6(3):480-487.
    [15] Trendelenburg G, Prass K, Priller J, et al.Serial analysis of gene expression identifies metallothionein-II as major neuroprotective gene in mouse focal cerebral ischemia.J Neurosci, 2,2(14):5 879-888.
    [16] Diaz-Ruiz A, Vacio-Adame P, Monroy-Noyola A, et al.Metallothionein-II inhibits lipid peroxidation and improves functional recovery after transient brain ischemia and reperfusion in rats.Oxid Med Cell Longev, 4,4:436 429.
    [17] Schulkens IA, Castricum KC, Weijers EM, et al.Expression, regulation and function of human metallothioneins in endothelial cells.J Vasc Res, 4,1(3):231-238.
    [18] Liu Y, Liu H, Chen W, et al.EOLA1 protects lipopolysaccharide induced IL-6 production and apoptosis by regulation of MT2A in human umbilical vein endothelial cells.Mol Cell Biochem, 4,5(1-2):45-51.
    [19] Albrecht EA, Dhanasekaran SM, Tomlins S.Immediate early inflammatory gene responses of human umbilical vein endothelial cells to hemorrhagic venom.Inflamm Res, 1,0(3):213-217.
    [20] Chen J, Jin TY.Influence of isoflavones on cadmium-induced adverse effects in vascular endothelial cells (ECV 304).Biomed Environ Sci, 5,8(3):146-152.
    [21] Liang Z, Yang Z.Identification and characterization of a novel gene EOLA1 stimulating ECV304 cell proliferation.Biochem Biophys Res Commun, 4,5(3):798-802.
    [22] Dong F, Li Q, Sreejayan N, et al.Metallothionein prevents high-fat diet induced cardiac contractile dysfunction:role of peroxisome proliferator activated receptor gamma coactivator 1alpha and mitochondrial biogenesis.Diabetes, 7,6(9):2 201-212.
    [23] Xu J, Wang G, Wang Y, et al.Diabetes- and angiotensin II-induced cardiac endoplasmic reticulum stress and cell death:metallothionein protection.J Cell Mol Med, 9,3(8A):1 499-512.
    [24] Yang L, Hu N, Jiang S, et al.Heavy metal scavenger metallothionein attenuates ER stress-induced myocardial contractile anomalies:role of autophagy.Toxicol Lett, 4,5(3):333-341.
    [25] Yang L, Wang J, Yang J, et al.Antioxidant metallothionein alleviates endoplasmic reticulum stress-induced myocardial apoptosis and contractile dysfunction.Free Radic Res, 5,9(10):1 187-198.
    [26] Ullio C, Brunk UT, Urani C, et al.Autophagy of metallothioneins prevents TNF-induced oxidative stress and toxicity in hepatoma cells.Autophagy, 5,1(12):2 184-198.
    [27] Duan Q, Wang T, Zhang N, et al.Propylthiouracil, perchlorate, and thyroid-stimulating hormone modulate high concentrations of iodide instigated mitochondrial superoxide production in the thyroids of metallothionein I/II knockout mice.Endocrinol Metab (Seoul), 6,1(1):174-184.
    [28] Bragina O, Gurjanova K, Krishtal J, et al.Metallothionein 2A affects the cell respiration by suppressing the expression of mitochondrial protein cytochrome c oxidase subunit II.J Bioenerg Biomembr, 5,7(3):209-216.
    [29] Kang YJ, Li Y, Sun X, et al.Antiapoptotic effect and inhibition of ischemia/reperfusion-induced myocardial injury in metallothionein-overexpressing transgenic mice.Am J Pathol, 3,3(4):1 579-586.
    [30] Leng W, Lei X, Meng H, et al.EOLA1 inhibits lipopolysaccharide-induced vascular cell adhesion molecule-1 expression by association with MT2A in ECV304 cells.Int J Inflam, 5,5:301 562.
    [31] Stankovic RK, Chung RS, Penkowa M.Metallothioneins I and II:neuroprotective significance during CNS pathology.Int J Biochem Cell Biol, 7,9(3):484-489.
    [32] Wu H, Zhou S, Kong L, et al.Metallothionein deletion exacerbates intermittent hypoxia-induced renal injury in mice.Toxicol Lett, 5,2(2):340-348.
    [33] 饶璇, 李元建.内皮细胞损伤与修复的研究进展.中国动脉硬化杂志, 7,5(5):531-535.
    Cited by
    Comments
    Comments
    分享到微博
    Submit
Get Citation

DAI Ming-Qiang, JIAO Rong, XU Cai-Xia, XIE Hui-Xing, LI Tian-Fa, LI Ji-Ke. Progress of metallothionein 2A in cardiovascular and cerebrovascular diseases[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2018,26(3):310-314.

Copy
Share
Article Metrics
  • Abstract:1443
  • PDF: 918
  • HTML: 0
  • Cited by: 0
History
  • Received:July 27,2017
  • Revised:September 18,2017
  • Online: April 03,2018
Article QR Code

You are the 31848 visitor

Post Code：421001 Fax：0734-8160523

Phone：0734-8160765 E-mail：dmzzbjb@163.net

Editorial Office of Chinese Journal of Arteriosclerosis ® 2025