Aim To investigate the relationship between serum uric acid on admission and incidence of contrast-induced nephropathy (CIN) in patients with coronary heart disease complicated with diabetes mellitus. Methods A total of 150 patients with coronary heart disease complicated with diabetes mellitus were divided into two groups:control group (n=95) and increased serum uric acid group (n=55). The incidence of CIN was compared between the two groups and the risk factors of CIN were analyzed by Logistic regression. Results The incidence of CIN in 55 patients with increased serum uric acid was 27.27% (15/55),and it was significantly higher than that in patients with normal serum uric acid [10.53%(10/95), P=0.008]. Multivariate Logistic regression analysis revealed that the independent risk factors of CIN were serum uric acid (OR 1.7,5% confidence interval:1.001～1.013, P=0.014) and contrast dosage (OR 1.5,5% confidence interval:1.017～1.054, P=0.000). Conclusion Increased serum uric acid on admission is independently associated with higher risk of CIN among patients with coronary heart disease complicated with diabetes mellitus.