Aim To investigate the association between the expression of Beclin-1 and ischemic cardiomyopathy.Methods Participants in case group (n＝80) were selected from autopsy cases accepted by Forensic Judicial Expertise Center of Guizhou Medical University from July 2013 to December 2016, pathologically confirmed to have suffered “ischemic cardiomyopathy”. And participants in control group (n＝122), the ones without myocardial tissue lesions, were selected from autopsy cases accepted during the same period. Beclin-1 was detected in all samples by immunohistochemistry.And the effect of Beclin-1 expression on ischemic cardiomyopathy was evaluated by establishing multiple Generalized Additive Models (GAM), adjusting the confounding factors such as gender, age, height, body mass index (BMI), left ventricular wall thickness (LVWT), right ventricular wall thickness (RVWT), alcohol abuse, Gensini score, previous myocardial infarction history (MI), hypertension, chronic kidney disease (CKD), and chronic respiratory disease. Results This research demonstrated that the expression of Beclin-1 in cardiomyocytes was positively correlated with ischemic cardiomyopathy (OR＝1.2,5％CI was 1.1～1.3, P＜0.001). After adjusting for other confounders, Beclin-1's effect on ischemic cardiomyopathy was that the expression of Beclin-1 increased by 0.01 units, and the risk of ischemic cardiomyopathy increased by 20%. Conclusion Beclin-1 is an independent risk factor for ischemic cardiomyopathy.