2025年4月16日 周三
Home > Archive>Volume 26, Issue 7, 2018 >749-756
PDF HTML XML Export Cite reminder
The structure and functional regulation of CD36 and its role in atherosclerosis
CSTR:
[cstr]
Author:
Affiliation:

Department of Clinical Laboratory, Drum Tower Clinical Medical College (Nanjing Gulou Hospital), Nanjing Medical University, Nanjing, Jiangsu 210008, China)

Clc Number:

R543.5

  • Article
    • | |
  • Metrics
    • |
  • Reference
    • |
  • Related
    • |
  • Cited by
    • | |
  • Comments
    Abstract:

    CD36 is a multifunctional transmembrane glycoprotein that binds to oxidized low density lipoprotein to induce monocyte transformation into foam cells and promotes the formation of atherosclerosis through inflammatory response, oxidative stress, platelet activation, macrophage trapping. Inhibition of CD36 expression or interference with its associated signaling pathways can significantly alleviate the severity of atherosclerosis. In addition, the high expression of CD36 in the tongue, nasal cavity, small intestine and brain promotes the body's intake and absorption of lipids, and increases the risk factors of metabolic diseases. Serum soluble CD36 is found as a component of circulating microparticles and may be as a predictor for atherosclerotic disease.

    Reference
    Related
    Cited by
Get Citation

PENG Lijun, ZHANG Kui, WEI Hongxia, LI Lei. The structure and functional regulation of CD36 and its role in atherosclerosis[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2018,26(7):749-756.

Copy
Share
Article Metrics
  • Abstract:
  • PDF:
  • HTML:
  • Cited by:
History
  • Received:December 18,2017
  • Revised:March 12,2018
  • Online: July 17,2018
Article QR Code

You are the 31896 visitor

Post Code：421001 Fax：0734-8160523

Phone：0734-8160765 E-mail：dmzzbjb@163.net

Editorial Office of Chinese Journal of Arteriosclerosis ® 2025