Ferroptosis:a new way of myocardial cell death after ischemia/reperfusion

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Ferroptosis:a new way of myocardial cell death after ischemia/reperfusion
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                        PENG JunPENG Jun
Department of Pharmacology, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, Hunan 410078, China
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Affiliation:Department of Pharmacology, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, Hunan 410078, China)
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Abstract:

Ferroptosis is a novel type of cell death, which is closely modulated by multiple signaling transduction pathways including iron homeostasis pathway, cystine/glutamate transporter (System XC－) pathway and voltage-dependent anion channel (VDAC) pathway. Although there is evidence that ferroptosis contributes to myocardial ischemia/reperfusion injury, many questions remain to be solved, such as which stage ferroptosis mainly appear following myocardial ischemia/reperfusion? Is it a necessary condition for the involvement of iron in ferroptosis? It is of significance for seeking novel drugs to protect the heart against ischemia/reperfusion injury once the mechanisms for ferroptosis are elucidated.

Key words:ferroptosis; ischemia/reperfusion; myocardial cell; iron homeostasis

Reference

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PENG Jun. Ferroptosis:a new way of myocardial cell death after ischemia/reperfusion[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2018,26(8):757-760.

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Received:April 01,2018
Revised:May 20,2018
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Online: July 17,2018
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