Current status of diagnosis and treatment of familial hypercholesterolemia in China

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Current status of diagnosis and treatment of familial hypercholesterolemia in China
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                        GE YilanGE Yilan
Peking Union Medical College & Fuwai Hospital of Chinese Academy of Medical Sciences & National Center for Cardiovascular Disease & National Clinical Research Center of Cardiovascular Diseases & State Key Laboratory of Cardiovascular Disease & China Oxford Center for International Medical Research, Beijing 100037, China
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LIU JiaminLIU Jiamin
Peking Union Medical College & Fuwai Hospital of Chinese Academy of Medical Sciences & National Center for Cardiovascular Disease & National Clinical Research Center of Cardiovascular Diseases & State Key Laboratory of Cardiovascular Disease & China Oxford Center for International Medical Research, Beijing 100037, China
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GAO YanGAO Yan
Peking Union Medical College & Fuwai Hospital of Chinese Academy of Medical Sciences & National Center for Cardiovascular Disease & National Clinical Research Center of Cardiovascular Diseases & State Key Laboratory of Cardiovascular Disease & China Oxford Center for International Medical Research, Beijing 100037, China
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ZHANG LihuaZHANG Lihua
Peking Union Medical College & Fuwai Hospital of Chinese Academy of Medical Sciences & National Center for Cardiovascular Disease & National Clinical Research Center of Cardiovascular Diseases & State Key Laboratory of Cardiovascular Disease & China Oxford Center for International Medical Research, Beijing 100037, China
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LI YanLI Yan
Peking Union Medical College & Fuwai Hospital of Chinese Academy of Medical Sciences & National Center for Cardiovascular Disease & National Clinical Research Center of Cardiovascular Diseases & State Key Laboratory of Cardiovascular Disease & China Oxford Center for International Medical Research, Beijing 100037, China
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WU HanWU Han
Peking Union Medical College & Fuwai Hospital of Chinese Academy of Medical Sciences & National Center for Cardiovascular Disease & National Clinical Research Center of Cardiovascular Diseases & State Key Laboratory of Cardiovascular Disease & China Oxford Center for International Medical Research, Beijing 100037, China
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JIANG LixinJIANG Lixin
Peking Union Medical College & Fuwai Hospital of Chinese Academy of Medical Sciences & National Center for Cardiovascular Disease & National Clinical Research Center of Cardiovascular Diseases & State Key Laboratory of Cardiovascular Disease & China Oxford Center for International Medical Research, Beijing 100037, China
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Affiliation:Peking Union Medical College & Fuwai Hospital of Chinese Academy of Medical Sciences & National Center for Cardiovascular Disease & National Clinical Research Center of Cardiovascular Diseases & State Key Laboratory of Cardiovascular Disease & China Oxford Center for International Medical Research, Beijing 100037, China)
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Abstract:

Familial hypercholesterolemia (FH) is the most common monogenic disorder of lipid metabolism. The total cholesterol levels begin to rise during fetal stage, which leads to premature coronary heart disease. The diagnosis of FH is based on the serum concentration of low density lipoprotein cholesterol (LDLC), xanthomas, premature coronary heart disease and genetic test. While early detection and intervention are all crucial to the prognosis, the diagnosis rate and LDLC control rates after lipid-lowering drug treatment are extremely low in China.

Key words:hypercholesterolemia; premature coronary artery disease; gene mutation; lipid-lowering drug

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GE Yilan, LIU Jiamin, GAO Yan, ZHANG Lihua, LI Yan, WU Han, JIANG Lixin. Current status of diagnosis and treatment of familial hypercholesterolemia in China[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2018,26(8):851-857.

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Received:April 10,2018
Revised:June 08,2018
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Online: July 17,2018
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