Aim To establish the multiple risk factors models for patients with coronary heart disease(CHD) of different genders and then quantitatively analyze the risk of all factors. Methods A total of 8028 CHD inpatients and a control group of 336 cases without significant coronary artery stenosis were enrolled consecutively from January 2009 to January 2018. And they were divided into 4 groups of female CHD (n=2894), male CHD (n=5134), female control(n=129) and male control (n=207). All demographic and clinical data were collected by the physicians and master degree candidates in the division of cardiology. Results The Logistic regression models of multiple risk factors were established for CHD by different genders. More than 55 years of age, dyslipidemia, type 2 diabetes mellitus and hypertension were all independent risk factors of CHD for different genders(P＜0.05). However, the same risk factor had dramatically different pathogenic effects on CHD in male and female. The odds ratio (OR) was markedly different for females and males patients, per 10-year increased over 55 years old (2.597 vs 1.424), dyslipidemia(3.297 vs 1.398), hypertension(1.484 vs. 1.800), type 2 diabetes mellitus(3.187 vs 2.303), respectively(all P＜0.05). In addition, the family history of CHD increased the risk of CHD attack in females by 3.714 times (P＜0.05). Comparatively speaking,the history of smoking increased the risk of CHD attack in males by 5.642 times (P＜0.05). Conclusions Dyslipidemia and type 2 diabetes mellitus may present higher risk of CHD attack in females than males. However, history of smoking and hypertension are much more dangerous for males with CHD.