Aim To investigate the effect of aortic valve calcification (AVC) on the clinical characteristics and prognosis of patients with acute coronary syndrome (ACS) undergone percutaneous coronary intervention (PCI). Methods A total of 68 ACS inpatients with echocardiographic AVC and 106 ACS controls without AVC undergone PCI were consecutively enrolled from January 2014 to January 2016 in the division of cardiology in our hospital. The clinical and angiographic data of the patients were collected and followed up for two years by two cardiology physicians. Results The prevalences of dyslipidemia (77.9% vs 38.7%), type 2 diabetes mellitus (47.1% vs 24.5%) and arrhythmia (37.3% vs 15.2%) were significantly higher in the AVC group than the control goup (all P＜0.05). In addition, the Gensini score was significantly higher in the AVC group than the control goup (P＜0.05). The multivariate Cox regression model showed that aortic valve calcification, arrhythmia and type 2 diabetes mellitus were all independent worse prognostic risk factors of ACS(all P＜0.05). Conclusions ACS patients with AVC undergone PCI presented with higher co-morbidities of dyslipidemia, type 2 diabetes mellitus and arrhythmia in this pilot study. AVC was associated with the severity of coronary stenosis and more stents implantation in ACS patients. Assessment of AVC by means of transthoracic echocardiography could be a valuable non-invasive method for risk stratification of ACS patients.