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Research progress on atherosclerosis induced by trimethylamine oxide and its prevention and treatment
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1.Department of General Practice, ;2.Department of Cardiology, the Third People's Hospital of Hainan Province, Sanya, Hainan 572000, China;3.Graduate School of Guangzhou Medical University, Guangzhou, Guangdong 510000, China)

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R54

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    Abstract:

    Trimethylamine oxide (TMAO) is a product which is formed by the metabolism of choline and other substances depending on the intestinal microflora. In recent years, studies at home and abroad have found that TMAO plays an important role in the occurrence and development of atherosclerosis (As). TMAO promotes As by mediating inflammatory signals and gene expression in vascular endothelial cells, increasing thrombosis risk, increasing scavenger receptor and promoting foam cell formation, influencing cholesterol transport pathways and metabolic pathways. This paper summarizes the related literatures in recent years, and finds that by controlling diet, regulating intestinal flora, inhibiting trimethylamine precursor metabolism, inhibiting flavin monooxygenase activity, TMAO level in blood circulation can be reduced and As progress can be prevented.

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WANG Huanhui, WANG Bei, QIN Yongmei, LIN Ling. Research progress on atherosclerosis induced by trimethylamine oxide and its prevention and treatment[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2019,27(2):175-179.

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History
  • Received:May 25,2018
  • Revised:July 13,2018
  • Online: January 21,2019
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