Dyslipidemia is a major risk factor for cardiovascular disease, especially elevated low density lipoprotein cholesterol (LDLC) significantly increases the incidence of atherosclerotic cardiovascular disease (ASCVD). Statins have shown to be effective in reducing serum LDLC, thereby reducing the risk of ASCVD. However, in the course of clinical application of statins, more and more studies show that statins have drug resistance. Studies have shown that statin resistance is mainly affected by drug absorption, transport, metabolism and drug action itself. Intensive study of statin resistance can provide theoretical basis for further revealing the action mechanism of statins, and hopefully provide a target for the development of new lipid-lowering drugs.