Aim To study the effect of A1166C polymorphism of angiotensin Ⅱ type 1 receptor gene (AGTR1) on arteriosclerosis. Methods Pulse wave velocity (PWV) was chosen as an index for evaluating arteriosclerosis. Topic-related English literatures were searched in PubMed, EMBASE, Cochrane Library and Web of Science. The retrieval time was from the establishment of the database to October 2018. Two authors independently selected appropriate observational studies based on the corresponding inclusion and exclusion criteria. Revman 5.2 software and STATA 11.0 software were used for Meta-analysis. Results A total of seven literatures (n＝1 687) was included in the Meta-analysis. The results showed that there was no significant correlation between AGTR1 A1166C polymorphism and PWV in general population and white population. In Asian population, the PWV of allele C carriers was significantly higher than that of AA genotype (AC＋CC vs AA:SMD＝0.3,5%CI 0.06-0.60, P＝0.02). Conclusions AGTR1 A1166C polymorphism may be associated with arteriosclerosis in Asians. Allele C may be a risk factor for PWV elevation in Asian population.