Aim To evaluate the association between left ventricular end-diastolic pressure (LVEDP) and contrast-induced nephropathy (CIN) in patients undergoing percutaneous coronary intervention (PCI). Methods Single center clinical data of patients who underwent PCI were retrospectively analysed to explore the predictive value of LVEDP for the occurrence of CIN. Results Among 1 301 patients who underwent PCI during the study period, 125 patients (9.61%) developed CIN. Risk factors for CIN included age, female, chronic kidney disease, history of diabetes mellitus, anemia, heart failure and emergencies in our study cohort. Compared with non-CIN group, the average LVEDP was higher in patients with CIN after PCI ((18.4±8.7) mmHg vs (14.4±6.6) mmHg, P<0.001). Multiple regression analysis showed that LVEDP (≥20 mmHg) could independently predict the occurrence of CIN (OR 1.6,5%CI 1.08～1.47). The predictive value of LVEDP for CIN was enhanced in patients with low ejection fraction. Contrast dosage in high-risk patients determined by elevated LVEDP was comparable to that in patients not found. Conclusions LVEDP is an independent predictor for CIN. Patients with elevated LVEDP (≥20 mmHg) are at higher risk of CIN after PCI. In CIN prevention, high-risk patients defined by elevated LVEDP need to be noticed by clinicians.