Aim To investigate the occurrence and risk factors of aortic valve calcification in patients with pneumoconiosis. Methods 194 cases with pneumoconiosis were selected as the research objects. According to the results of color Doppler echocardiography, they were divided into calcification group and non-calcification group. Another 200 healthy persons with normal physical examination during the same period were selected as the control group. To observe the occurrence of aortic valve calcification in patients with pneumoconiosis and healthy persons, firstly, sex, age, body mass index (BMI), smoking history, hypertension history, diabetes history, heart rate, blood pressure, fasting blood glucose (FBG), triglyceride (TG), total cholesterol (TC), very low density lipoprotein cholesterol (VLDLC), low density lipoprotein cholesterol (LDLC), high density lipoprotein cholesterol (HDLC), lipoprotein a (Lp(a)) were analyzed by single factor analysis between the two groups, and then, with or without aortic valve calcification as dependent variable, multivariate Logistic regression analysis was made on the single factor with statistical significance between the two groups of pneumoconiosis patients. Results Among 194 patients with pneumoconiosis, the incidence of aortic valve calcification was 20.10%. Among 200 healthy people, the incidence of aortic valve calcification was 12.00%. The incidence of aortic valve calcification in pneumoconiosis patients was significantly higher than that in healthy people (P<0.05). There were significant differences in age, history of hypertension, systolic blood pressure, FBG, TC and TG among pneumoconiosis patients (P<0.05). Further Logistic regression analysis showed that age (OR=2.6,5%CI 1.448～3.639), systolic blood pressure (OR=3.9,5%CI 1.871～6.433), and TG (OR=3.2,5%CI 1.699～6.146) were independent risk factors for aortic valve calcification in patients with pneumoconiosis. Conclusion In patients with pneumoconiosis, the incidence of aortic valve calcification is higher, and age, systolic pressure and TG are independent risk factors for aortic valve calcification in patients with pneumoconiosis, and monitoring the above indicators can provide predictive value for the occurrence of aortic valve calcification in patients with pneumoconiosis.