In lupus nephritis, laboratory indicators such as serum creatinine and urinary protein are often used to evaluate disease activity and curative effect, but these indicators are not necessarily positively correlated with renal activity and renal pathological types. Although renal biopsy is a golden index for evaluating pathological changes, it is invasive It seems that the microRNA(miRNA) in human body fluid are correlated with the diagnosis of lupus nephritis, the assessment of disease activity and the pathological type of kidney.