Aim To explore relationship between serum pentraxin 3(PTX-3), progranulin(PGRN) and blood pressure variability in essential hypertension patients with obstructive sleep apnea hypopnea syndrome (OSAHS). Methods 241 cases of essential hypertension patients with OSAHS were selected as the observation subjects. According to the apnea hypopnea index(AHI) (mild:AHI 5~15 times/h; moderate:AHI 16~0 times/h; severe:AHI>31 times/h), the patients were divided into mild group (n=136), moderate group (n=45) and severe group (n=60). The baseline data, serum PTX-3 and PGRN, blood pressure variability and the correlation between serum factors and blood pressure variability were compared and analyzed. Pearson and muti-line regression were employed to analyse the relationship between PTX-3, PGRN and blood pressure variability. Results There were significant differences in serum PTX-3 and PGRN levels among the three groups (P<0.05), and there were significant differences in night blood pressure variability among the three groups (P<0.05). Serum PTX-3 was positively correlated with night systolic blood pressure standard deviation(nSSD) (r=0.484, P<0.001) and night diastolic blood pressure standard deviation(nDSD) (r=0.349, P<0.001). Serum PGRN was positively correlated with nSSD (r=0.361, P<0.001) and nDSD (r=0.301, P<0.001). PTX-3 and PGRN were independent risk factors for nSSD and nDSDD. Conclusion Serum PTX-3 and PGRN were positively correlated with nocturnal blood pressure variability in essential hypertension patients with OSAHS. Serum level of PTX-3 and PGRN were independent risk factors of nocturnal blood pressure variability.