Aim To investigate the influencing factors of quality of life in patients with hypertensive cerebral hemorrhage in the basal ganglia after minimally invasive hematoma evacuation. Methods A retrospective analysis of 80 patients with hypertensive cerebral hemorrhage in the basal ganglia with minimally invasive hematoma evacuation in our hospital from January 2012 to January 2015 was performed, a single factor analysis of the factors affecting postoperative quality of life and Logistic regression analysis was performed to investigate the independent influencing factors of quality of life in patients with hypertensive cerebral hemorrhage in the basal ganglia undergoing minimally invasive puncture hematoma evacuation. Results Univariate analysis showed that the patient age, family size, marital status, education level, family monthly income, midline shift, cerebral hemorrhage, cerebral palsy and cerebral ventricle, and patient consciousness have significant effects on postoperative physical health of patients (P<0.05); family size, whether living with children, marital status, and state of consciousness were significant factors affecting postoperative mental health (P<0.05); multivariate analysis showed that the number of family members (OR=1.1,5% CI 1.175~3.206) and midline displacement (OR=0.9,5% CI 0.363~0.956), cerebral hemorrhage (OR=10.3,5% CI 6.099~ 17.235) is an independent influencing factor affecting postoperative physical health; marital status (OR=0.7,5% CI 0.357~0.664) and whether or not living with children (OR=5.2,5% CI 5.145~5.652) is affecting patients independent influence factors of post-mental health. There was a significant negative correlation between family size, midline displacement, and cerebral hemorrhage and physical health scores. Marriage status was significantly negatively correlated with mental health scores, and positively correlated with children's living and mental health scores. Conclusion The quality of life of patients with hypertensive cerebral hemorrhage in the basal ganglia is significantly related to the patient's family size, brain midline shift, cerebral hemorrhage, and whether they live with their children or marital status.