Aim To research the connection between the changes of plasma platelet-derived growth factor C (PDGF-C) concentration and coronary heart disease and the degree of coronary artery disease. Methods The research includes 52 patients with acute coronary syndrome (ACS), 52 patients with stable angina pectoris (SAP), and 50 patients with normal angiography as the control group. Among patients with coronary heart disease (ACS and SAP), there were 60 cases of coronary artery multivessel disease, 25 cases of double vessel disease, and 19 cases of single vessel disease. The enzyme-linked immunosorbent assay (ELISA) method was used to determine the plasma PDGF-C concentration in each group of patients. The plasma PDGF-C concentration levels were compared between groups, and Spearman correlation analysis, Logistic regression analysis, and ROC curve were drawn. Results The concentration of PDGF-C in the ACS group and the SAP group was higher than that in the control group(P<0.05). The plasma PDGF-C concentration in the multivessel and double disease groups was higher than that in the single disease group(P<0.05). The results of Spearman correlation analysis indicated that there was a correlation between plasma PDGF-C concentration and Gensini score(r=0.163, P<0.05). Logistic regression analysis found that patients with high concentration of PDGF-C had a higher risk of coronary heart disease than patients with low concentration of PDGF-C (OR=1.6,5%CI 1.002~1.011). The area under the ROC curve of plasma PDGF-C concentration was 0.645, and the sensitivity was 77.88%.Conclusion High-concentration plasma PDGF-C may be a risk factor for coronary heart disease and may be related to the severity of coronary artery disease.