With the progress of genome-wide analysis and RNA sequencing technology, a variety of non-coding RNA has gradually become a research hotspot. Circular RNA (circRNA) has many cellular functions, and its expression changes are related to many pathophysiological processes and the occurrence and development of diseases. The circRNA has been proved to be an important regulator of cardiovascular diseases, such as hypertension, atherosclerosis, acute myocardial infarction, heart failure, cardiac fibrosis, etc. Therefore, circRNA is expected to be a potential therapeutic target and biomarker for cardiovascular diseases. In this review, based on the biological mechanism of circRNA, we reviewed the current research progress on circRNA as a regulatory factor and biomarker of cardiovascular diseases.