The pathological characteristic of coronary heart disease (CHD)is rupture or erosion of atherosclerotic plaques of coronary artery which induces platelet aggregation, thrombosis, coronary artery spasm,microvascular embolism.They cause acute or subacute hypoxia or ischemia of myocardium. Studies show that coronary arterial endothelial cells can differentiate from venous endothelial cells. This review illustrates the classification of angiogenesis , the process of differentiation and clinical significance of coronary venous endothelial cells to arterial endothelial cells and the exploration of potential therapeutic targets. It aimed at providing reference for the future coronary angiogenesis.