Aim To explore the correlation between lipid deposition index and atherosclerosis of coronary heart disease (CHD) and optimize the best index to provide reference for clinical diagnosis and treatment. Methods 231 patients who underwent coronary angiography from January 2018 to February 2019 were selected. According to the results of coronary angiography, the patients were divided into three groups:non-CHD group (n＝75), CHD non-intervention group (n＝80), and CHD intervention group (n＝76). Routine biochemistry and full set of blood lipid indexes were detected by automatic biochemical analyzer. The correlation between lipid deposition index and the degree of atherosclerosis was analyzed. ROC curve was used to analyze the specificity and sensitivity of lipid deposition index in predicting CHD.Results There were significant differences in age, body mass index, total cholesterol, low density lipoprotein cholesterol (LDLC), high density lipoprotein cholesterol, apolipoprotein B, apolipoprotein A1, homocysteine (Hcy), C-reactive protein (CRP) and cardiac troponin I among the three groups (P＜0.05). Logistic regression analysis showed that lipid deposition index A,Dü and E were positively correlated with the degree of atherosclerosis in CHD (P＜0.05), among which the correlation of lipid deposition index E composed of LDLC×age×Hcy×CRP was the highest. ROC curve analysis showed that the area under curve of lipid deposition index E was 0.618, the specificity was 0.911, and the sensitivity was 0.767, which was the highest in predicting CHD. Conclusion There is a significant positive correlation between lipid deposition index E and the degree of atherosclerosis in CHD. Lipid deposition index E can highly predict the degree of coronary artery lesions.