Aim To explore the current situation, hotspots and trends of blood lipid research in Chinese population from 2009 to 2019. Methods From 2009 to 2019, literatures related to blood lipid research were retrieved on China National Knowledge Infrastructure (CNKI). Bibliographic item co-occurrence matrix builder (BICOMB) and graphical clustering toolkit (gCLUTO) were used for word frequency analysis and clustering analysis. Results A total of 3 022 literatures were searched, with 47 high-frequency words and with frequency greater than or equal to 31. The results of cluster analysis showed that from 2009 to 2019, the research hotspots of blood lipid in China mainly focused on five aspects:the epidemiology of hyperlipidemia in Chinese population, the chronic diseases related to lipids or atherosclerosis, the theory of oxidized low density lipoprotein cholesterol fat, lipid regulating drugs, and Chinese characteristic lipid regulating therapy. Conclusion Many scholars are committed to the study of disease mechanism, lipid-lowering treatment strategy and new drug research and development, but the study of non-drug intervention in lipid management is very rare, so it is urgent to carry out health education in nursing and promote intervention, so as to improve the awareness rate, treatment rate and standard-reaching rate of lipid management.