Research progress on fatty acid binding protein and diabetic vasculopathy

Home > Archive>Volume 28, Issue 8, 2020 >673-678

Research progress on fatty acid binding protein and diabetic vasculopathy
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                        LIU JinhanLIU Jinhan
Department of Metabolism and Endocrinology & Key Laboratory of Diabetes Immunology, Ministry of Education & National Clinical Research Center for Metabolic Diseases, the Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China
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ZHOU ZhiguangZHOU Zhiguang
Department of Metabolism and Endocrinology & Key Laboratory of Diabetes Immunology, Ministry of Education & National Clinical Research Center for Metabolic Diseases, the Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China
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XIAO YangXIAO Yang
Department of Metabolism and Endocrinology & Key Laboratory of Diabetes Immunology, Ministry of Education & National Clinical Research Center for Metabolic Diseases, the Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China
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Affiliation:Department of Metabolism and Endocrinology & Key Laboratory of Diabetes Immunology, Ministry of Education & National Clinical Research Center for Metabolic Diseases, the Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China)
Clc Number:R54
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Abstract:

The prevalence of diabetes is increasing globally. Diabetic vascular complications are the primary cause of death and disability in the elderly at present. Fatty acid binding protein (FABP), a family of lipid chaperones, is a key inflammatory molecule linking obesity, diabetes and vascular diseases, and plays an important role in diabetic vasculopathy. This article reviews the molecular mechanism of FABP family members in the occurrence and development of diabetes mellitus and its vasculopathy, the therapeutic value as intervention target and the clinical significance as biomarkers, in order to provide evidence and ideas for the research and development of anti-diabetic vasculopathy drugs represented by FABP.

Key words:fatty acid binding protein; diabetic vasculopathy; atherosclerosis

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LIU Jinhan, ZHOU Zhiguang, XIAO Yang. Research progress on fatty acid binding protein and diabetic vasculopathy[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2020,28(8):673-678.

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Received:May 15,2020
Revised:May 27,2020
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Online: July 03,2020
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