Aim To analyze the clinical and echocardiographic characteristics of patients with amyloidosis diagnosed by renal biopsy, in order to provide help for the early diagnosis of patients with myocardial amyloidosis. Methods This study included a total of 45 patients with amyloidosis nephropathy diagnosed by renal biopsy. Clinical data (age, gender, blood pressure, etc) and ultrasonic cardiac indicators (interventricular septal thickness, left ventricular end-diastolic diameter, left ventricular ejection fraction, etc) of patients undergoing renal biopsy were collected, and the differences of indicators and prognosis between patients with and without cardiac involvement were compared. ResultsThe interventricular septal thickness and left ventricular posterior wall thickness increased in patients with cardiac involvement compared with the patients without cardiac involvement (P＜0.05). The median survival time was 15 months in patients with cardiac involvement, which was significantly lower than that of patients without cardiac involvement(P＜0.05).Conclusion The echocardiography of patients with amyloidosis diagnosed by renal biopsy indicates that both interventricular septal thickness and left ventricular posterior wall thickness increase, and the interventricular septal thickness is more than 10 mm, which can be used as the early basis to determine whether the patients are complicated with myocardial amyloidosis.