The correlation between concentrations of size-dependent circulating microparticles from patients and the dose of positive inotropic medicine undergoing cardiac surgery with cardiopulmonary bypass

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The correlation between concentrations of size-dependent circulating microparticles from patients and the dose of positive inotropic medicine undergoing cardiac surgery with cardiopulmonary bypass
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                        MA Jian1,2MA Jian
Division of Cardiac Surgery, Heart Center, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510080, China;National-Guangdong Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Diseases & NHC key Laboratory of Assisted Circulation Sun Yat-sen University & Guangdong Provincial Engineering and Technology Center for Diagnosis and Treatment of Vascular Diseases & Guangdong Provincial Key Laboratory of Brain Function and Disease, Guangzhou, Guangdong 510080, China
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CHEN Yating1,2CHEN Yating
Division of Cardiac Surgery, Heart Center, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510080, China;National-Guangdong Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Diseases & NHC key Laboratory of Assisted Circulation Sun Yat-sen University & Guangdong Provincial Engineering and Technology Center for Diagnosis and Treatment of Vascular Diseases & Guangdong Provincial Key Laboratory of Brain Function and Disease, Guangzhou, Guangdong 510080, China
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CHEN Chao1,2CHEN Chao
Division of Cardiac Surgery, Heart Center, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510080, China;National-Guangdong Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Diseases & NHC key Laboratory of Assisted Circulation Sun Yat-sen University & Guangdong Provincial Engineering and Technology Center for Diagnosis and Treatment of Vascular Diseases & Guangdong Provincial Key Laboratory of Brain Function and Disease, Guangzhou, Guangdong 510080, China
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LI Yuquan1,2LI Yuquan
Division of Cardiac Surgery, Heart Center, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510080, China;National-Guangdong Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Diseases & NHC key Laboratory of Assisted Circulation Sun Yat-sen University & Guangdong Provincial Engineering and Technology Center for Diagnosis and Treatment of Vascular Diseases & Guangdong Provincial Key Laboratory of Brain Function and Disease, Guangzhou, Guangdong 510080, China
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YUAN Haoxiang1,2YUAN Haoxiang
Division of Cardiac Surgery, Heart Center, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510080, China;National-Guangdong Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Diseases & NHC key Laboratory of Assisted Circulation Sun Yat-sen University & Guangdong Provincial Engineering and Technology Center for Diagnosis and Treatment of Vascular Diseases & Guangdong Provincial Key Laboratory of Brain Function and Disease, Guangzhou, Guangdong 510080, China
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JIAN Yupeng1,2JIAN Yupeng
Division of Cardiac Surgery, Heart Center, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510080, China;National-Guangdong Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Diseases & NHC key Laboratory of Assisted Circulation Sun Yat-sen University & Guangdong Provincial Engineering and Technology Center for Diagnosis and Treatment of Vascular Diseases & Guangdong Provincial Key Laboratory of Brain Function and Disease, Guangzhou, Guangdong 510080, China
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LI Yan1,2LI Yan
Division of Cardiac Surgery, Heart Center, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510080, China;National-Guangdong Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Diseases & NHC key Laboratory of Assisted Circulation Sun Yat-sen University & Guangdong Provincial Engineering and Technology Center for Diagnosis and Treatment of Vascular Diseases & Guangdong Provincial Key Laboratory of Brain Function and Disease, Guangzhou, Guangdong 510080, China
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OU Zhijun2,3OU Zhijun
National-Guangdong Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Diseases & NHC key Laboratory of Assisted Circulation Sun Yat-sen University & Guangdong Provincial Engineering and Technology Center for Diagnosis and Treatment of Vascular Diseases & Guangdong Provincial Key Laboratory of Brain Function and Disease, Guangzhou, Guangdong 510080, China;Division of Hypertension and Vascular Diseases, Heart Center, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510080, China
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OU Jingsong1,2OU Jingsong
Division of Cardiac Surgery, Heart Center, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510080, China;National-Guangdong Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Diseases & NHC key Laboratory of Assisted Circulation Sun Yat-sen University & Guangdong Provincial Engineering and Technology Center for Diagnosis and Treatment of Vascular Diseases & Guangdong Provincial Key Laboratory of Brain Function and Disease, Guangzhou, Guangdong 510080, China
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Affiliation:1.Division of Cardiac Surgery, Heart Center, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510080, China;2. National-Guangdong Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Diseases & NHC key Laboratory of Assisted Circulation (Sun Yat-sen University) & Guangdong Provincial Engineering and Technology Center for Diagnosis and Treatment of Vascular Diseases & Guangdong Provincial Key Laboratory of Brain Function and Disease, Guangzhou, Guangdong 510080, China;3. Division of Hypertension and Vascular Diseases, Heart Center, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510080, China)
Clc Number:R604
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Abstract:

Aim This study analyzed the relationship between the concentration of circulating microparticles (MPs) with different diameters and the application of positive inotropic drugs in the patients undergoing cardiac surgery with cardiopulmonary bypass (CPB). It aims to find out the effects of MPs on the postoperative cardiac function. Methods 103 patients undergoing cardiac surgery with CPB were enrolled. Age and gender matched 56 healthy subjects were recruited as control group. The blood was collected from healthy subjects and patients before (pre-op) and after operation 12 h (post-op 12 h) and 72 h (post-op 72 h). The MPs were isolated by differential centrifugation. The concentration and size distribution of MPs were detected by nanoparticle tracking analysis system. MPs were divided into different subgroups according to the size of MPs. The clinical data were collected and the correlation analysis was performed between the MPs and the clinical data. Results The level of MPs was increased in patients before and after surgery compared with healthy subjects (P＜0.05). There was no significant difference of the concentration of MPs in the surgery group among the different time points (pre-op, post-op 12 h and post-op 72 h). The MPs were divided into four groups according to the diameter (0~100 nm, 100~200 nm, 200~300 nm and 300~400 nm). The levels of “100~200 nm” MPs were decreased in post-op 12 h and post-op 72 h groups compared with pre-op group, but the levels of “200~300 nm” MPs were increased after operation(P＜0.05). In post-op 12 h group, the concentration of “0~100 nm” MPs was negatively correlated with N terminal pro B type natriuretic peptide (NT-proBNP), dopamine, norepinephrine and milrinone and the level of “200~300 nm” MPs was positively correlated with NT-proBNP (P＜0.05). In post-op 72 h group, the level of “0~100 nm” MPs was negatively correlated with NT-proBNP (P＜0.05) and the concentration of “200~300 nm” MPs was negatively correlated with dobutamine (P＜0.05). Conclusions After CPB assisted cardiac surgery, MPs with different particle size range was correlated with postoperative positive inotropic drug dosage, suggesting that there was a certain relationship between MPs and postoperative cardiac function. The concentration of MPs in different size may be used to reflect the cardiac function after CPB.

Key words:circulating microparticles; cardiopulmonary bypass; cardiac insufficiency; positive inotropic drugs

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MA Jian, CHEN Yating, CHEN Chao, LI Yuquan, YUAN Haoxiang, JIAN Yupeng, LI Yan, OU Zhijun, OU Jingsong. The correlation between concentrations of size-dependent circulating microparticles from patients and the dose of positive inotropic medicine undergoing cardiac surgery with cardiopulmonary bypass[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2020,28(10):847-851.

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Received:May 28,2020
Revised:August 20,2020
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Online: October 20,2020
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