Physiological angiogenesis plays an important role in tissue repair and body balance, but abnormal angiogenesis can induce a variety of diseases, such as cancer, ischemic heart disease and stroke. Regulation of angiogenesis is of great significance for the treatment of many diseases. Anti-angiogenic therapy has shown therapeutic significance in certain diseases, but pro-angiogenic therapy remains a difficult problem. In recent years, a large number of studies have shown that long noncoding RNA (lncRNA) plays an important role in angiogenesis. By regulating abnormal lncRNA, angiogenesis can be inhibited or promoted, which opens up a new field for the treatment of diseases related to abnormal angiogenesis.