New progress in the study of structure, metabolism and function of high density lipoprotein

Home > Archive>Volume 28, Issue 10, 2020 >911-916

New progress in the study of structure, metabolism and function of high density lipoprotein
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                        ZHOU Li1ZHOU Li
Institute of Cardiovascular Disease & Key Laboratory for Arteriosclerology of Hunan Province & Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic Disease & Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang, Hunan 421001, China
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LI Junyi2LI Junyi
School of Nursing, University of South China, Hengyang, Hunan 421001, China
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HE Pingping2HE Pingping
School of Nursing, University of South China, Hengyang, Hunan 421001, China
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TANG Chaoke1TANG Chaoke
Institute of Cardiovascular Disease & Key Laboratory for Arteriosclerology of Hunan Province & Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic Disease & Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang, Hunan 421001, China
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Affiliation:1.Institute of Cardiovascular Disease & Key Laboratory for Arteriosclerology of Hunan Province & Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic Disease & Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang, Hunan 421001, China;2.School of Nursing, University of South China, Hengyang, Hunan 421001, China)
Clc Number:R5；R363
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Abstract:

High density lipoprotein (HDL) is mainly composed of apolipoprotein A1 (ApoA1), lipid and related regulatory factors. Its structural and functional abnormalities are closely related to the occurrence and development of cardiovascular diseases. HDL mainly transports cholesterol from the macrophages under the endothelium of blood vessels to the liver and expels it through the reverse cholesterol transport pathway, regulating the lipid balance in the body. It is found that the structure and metabolism of HDL have changed in patients with cardiovascular disease, including the abnormal modification of ApoA1, serum amyloid A instead of ApoA1 and the change of miRNA content carried by HDL. This article reviews the structure, metabolism and function of HDL, which provides a new way for the diagnosis and treatment of lipid metabolism related diseases.

Key words:high density lipoprotein; apolipoprotein A1; serum amyloid A; reverse cholesterol transport; atherosclerosis; age-related macular degeneration

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ZHOU Li, LI Junyi, HE Pingping, TANG Chaoke. New progress in the study of structure, metabolism and function of high density lipoprotein[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2020,28(10):911-916.

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Received:September 22,2019
Revised:February 24,2020
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Online: October 20,2020
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