m⁶A methyladenosine is a methylation modification catalyzed by methyltransferase at the 6th position nitrogen atom of adenine (A), which is the most common chemical modification on eukaryotic messenger RNA (mRNA). Recently, m⁶A has been found to play an important role in the dynamic regulation of RNA, which is crucial for the basic physiological processes such as adipogenesis, cell differentiation and immune/inflammatory response. Metabolic diseases are series of disorders caused by metabolic dysfunction of proteins, glucose and lipid in the body. The studies have shown that m⁶A methylation plays a key role in the development of metabolic diseases such as obesity, type 2 diabetes and cardiovascular diseases via regulation of glucose/lipid metabolism and immune/inflammation. This paper will review the role of m⁶A methylation in metabolic diseases, which may provide new ideas for the prevention and treatment of metabolic diseases from the perspective of epitranscriptome.