Review and prospect on the mechanism of myocardial ischemia-reperfusion injury

Home > Archive>Volume 28, Issue 12, 2020 >1013-1019

Review and prospect on the mechanism of myocardial ischemia-reperfusion injury
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                        LIU Danyong1LIU Danyong
Department of Anesthesiology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong 524000, China
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XIA Zhengyuan1,2XIA Zhengyuan
Department of Anesthesiology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong 524000, China;Department of Anesthesiology, University of Hong Kong, Hong Kong 999077, China
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HAN Ronghui1HAN Ronghui
Department of Anesthesiology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong 524000, China
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CHEN Hao1CHEN Hao
Department of Anesthesiology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong 524000, China
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LIU Xin1LIU Xin
Department of Anesthesiology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong 524000, China
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TANG Jing1TANG Jing
Department of Anesthesiology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong 524000, China
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Affiliation:1.Department of Anesthesiology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong 524000, China;2.Department of Anesthesiology, University of Hong Kong, Hong Kong 999077, China)
Clc Number:R54
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Abstract:

Myocardial infarction is one of the leading causes of death in patients with coronary heart disease worldwide. In the early stage of acute myocardial infarction, percutaneous coronary intervention, coronary artery bypass grafting, drugs and other treatment means can restore the blood supply of ischemic myocardial tissue, save the dying myocardium and reduce the mortality rate of patients. However, after the interruption of myocardial blood supply and the restoration of blood supply within a certain period of time, the original ischemic myocardium may suffer more serious damage than that of ischemia. This phenomenon is called myocardial ischemia-reperfusion injury (MIRI), and its mechanism has not been fully elucidated. In this paper, the research progress of MIRI mechanism in recent years is reviewed, and the pathophysiological mechanism of MIRI is expounded, which will help to develop new therapeutic interventions and provide help for clinical treatment of myocardial infarction.

Key words:myocardial ischemia-reperfusion injury; calcium overload; oxidative stress; autophagy; cell apoptosis; pyroptosis; programmed necrosis

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LIU Danyong, XIA Zhengyuan, HAN Ronghui, CHEN Hao, LIU Xin, TANG Jing. Review and prospect on the mechanism of myocardial ischemia-reperfusion injury[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2020,28(12):1013-1019.

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Received:June 15,2020
Revised:September 07,2020
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Online: December 14,2020
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