Aim To evaluate the effects of high-dose (＞300 mL) iodixanol on renal function of diabetic patients within 72 hours after percutaneous coronary intervention (PCI) . Methods From October 2015 to December 7,7 patients who received high-dose (＞300 mL) iodixanol during PCI in four centers were selected. Finally, 204 cases were enrolled in this study. The incidence of contrast-induced acute kidney injury (CI-AKI) was evaluated. ResultsThe incidence of CI-AKI was 3.9% (8/204). In patients administered 300～500 mL and ＞500 mL iodixanol, the incidence of CI-AKI was 4.3% (7/161) and 2.3% (1/43), respectively. In the subgroup with pre-PCI estimated glomerular filtration rate (eGFR)＜60 mL/(min·1.73 m²), the incidence of CI-AKI was 6.9%(2/29). Multivariate Logistic regression analysis showed independent risk factors for CI-AKI were chronic renal failure, anemia, emergency PCI, and high Mehran score, but not contrast volume. Conclusion The administration of high-dose (＞300 mL) iodixanol in patients with diabetes undergoing PCI does not result in high incidences of post-PCI CI-AKI.