The occurrence and development of cardiovascular disease are closely related with intestinal cholesterol metabolism, so cardiovascular events can be efficiently reduced by regulating intestinal cholesterol metabolism balance. Natural medicines can regulate cholesterol metabolism level by regulating cholesterol absorption and transport in intestinal tract. So all natural medicines which suppressed cardiovascular disease by regulating cholesterol metabolism were summarized in recent years in order to provide reference for the prevention and treatment for cardiovascular disease induced by dyslipidemia.