Circular RNA (circRNA) is a new member of the non-coding RNA family, and because of its closed ring structure, it can be stably expressed in human blood. Lipid metabolism is one of the important biochemical reactions in human body, in which the processes closely related to atherosclerosis(As) are the endogenous pathway of lipid metabolism and reverse cholesterol transport(RCT). Abnormal lipid metabolism on the one hand is that excessive cholesterol accumulated in the cell can not be excreted to the liver for degradation, on the other hand, it will cause oxidative modification of low density lipoprotein(LDL) to oxidized low density lipoprotein(ox-LDL), which will also produce toxicity to cells while forming foam cells, and cause As. This paper summarizes that circRNA regulates RCT and the formation of ox-LDL to participate in the occurrence of As. At the same time, its stability is expected to become a new biomarker of As and provide a new research direction for the diagnosis and treatment of As.