Research progress of the genetic variations in lipid metabolism related with premature coronary heart disease

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Research progress of the genetic variations in lipid metabolism related with premature coronary heart disease
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                        PENG Qin1PENG Qin
Cardiovasology Department, Nanhua Hospital Affiliated to University of South China, Hengyang, Hunan 421002, China
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ZHOU Qinyi1ZHOU Qinyi
Cardiovasology Department, Nanhua Hospital Affiliated to University of South China, Hengyang, Hunan 421002, China
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HUANG Ke1HUANG Ke
Cardiovasology Department, Nanhua Hospital Affiliated to University of South China, Hengyang, Hunan 421002, China
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MA Xiaofeng1MA Xiaofeng
Cardiovasology Department, Nanhua Hospital Affiliated to University of South China, Hengyang, Hunan 421002, China
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JIANG Zhisheng2JIANG Zhisheng
Institute of Cardiovascular Disease & Key Laboratory for Arteriosclerology of Hunan Province & International Laboratory for Scientific Innovation and Co-operation of Hunan Province, University of South China, Hengyang, Hunan 421001, China
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Affiliation:1.Cardiovasology Department, Nanhua Hospital Affiliated to University of South China, Hengyang, Hunan 421002, China;2.Institute of Cardiovascular Disease & Key Laboratory for Arteriosclerology of Hunan Province & International Laboratory for Scientific Innovation and Co-operation of Hunan Province, University of South China, Hengyang, Hunan 421001, China)
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Abstract:

Premature coronary heart disease(pCHD)is a special type of cardiovascular disease. Recent research has demonstrated that pCHD possesses a strong genetic basis, genetic factors account for almost 50%~60% morbidity rate of pCHD, and lipid metabolism gene plays the most important role in it. Genetic variations of lipid metabolism can lead to the impediment of lipid synthesis and catabolism, as well as a series of disease characterized by atherosclerosis(As)and pCHD.This review aims to give a brief summary of the relationship between the genetic variations of lipid metabolism and pCHD.

Key words:premature coronary heart disease; atherosclerosis; lipid metabolism; genetic variation

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PENG Qin, ZHOU Qinyi, HUANG Ke, MA Xiaofeng, JIANG Zhisheng. Research progress of the genetic variations in lipid metabolism related with premature coronary heart disease[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2021,29(3):264-270.

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Received:August 15,2020
Revised:October 03,2020
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Online: March 02,2021
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