Atherosclerosis is a chronic inflammatory disease of large and medium-sized arteries, which can lead to ischemic heart disease, stroke, peripheral vascular disease and other cardiovascular and cerebrovascular diseases, seriously endangering human health. Intraplaque hemorrhage is an important feature of advanced plaque, and it has been proved that it can accelerate the progression of plaque in a short time, which is mainly related to the influence of blood cells into the plaque on the level of inflammation in the plaque. The purpose of this paper is to review the role of blood cell components in the regulation and outcome of inflammation in hemorrhagic plaque.