The research progress on mitochondrial dysfunction and vascular endothelial cell injury

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The research progress on mitochondrial dysfunction and vascular endothelial cell injury
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                        YAN Mingjing1,2YAN Mingjing
The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital/National Center of Gerontology of National Health Commission, Beijing 100730, China;Peking University Fifth School of Clinical Medicine, Beijing 100730, China
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SHEN Tao1,2SHEN Tao
The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital/National Center of Gerontology of National Health Commission, Beijing 100730, China;Peking University Fifth School of Clinical Medicine, Beijing 100730, China
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Affiliation:1.The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital/National Center of Gerontology of National Health Commission, Beijing 100730, China;2.Peking University Fifth School of Clinical Medicine, Beijing 100730, China)
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Abstract:

Mitochondrial dysfunction can lead to ATP decrease and reactive oxygen species increase in cells. Therefore, mitochondrial dysfunction is considered to be one of the culprit factors of vascular endothelial cell injury. Many causes are related to mitochondrial dysfunction including mitochondrial DNA mutations, mitochondrial fusion and fission imbalance, and mitophagy dysfunction. This review discussed the regulation mechanisms of mitochondrial quality control and mitochondrial dysfunction in vascular endothelial cell injury, which provide new ideas for the effective prevention and treatment of atherosclerosis.

Key words:endothelial injury; mitochondrial dysfunction; mitochondrial fusion and fission; mitophagy; mitochondrial DNA mutation

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YAN Mingjing, SHEN Tao. The research progress on mitochondrial dysfunction and vascular endothelial cell injury[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2021,29(10):829-837.

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Received:March 31,2021
Revised:April 26,2021
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Online: October 13,2021
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