Epigenetic regulation of vascular calcification

Home > Archive>Volume 29, Issue 10, 2021 >838-844

Epigenetic regulation of vascular calcification
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                        ZHONG Hui1ZHONG Hui
Biomedical Research Center, Basic Medical School, Guangzhou Medical University, Guangzhou, Guangdong 511436, China
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WANG Suying2WANG Suying
Department of Biochemistry and Molecular Biology, School of Life Sciences, Guangzhou Medical University, Guangzhou, Guangdong 511436, China
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LI Daiying2LI Daiying
Department of Biochemistry and Molecular Biology, School of Life Sciences, Guangzhou Medical University, Guangzhou, Guangdong 511436, China
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CHEN Jieyi2CHEN Jieyi
Department of Biochemistry and Molecular Biology, School of Life Sciences, Guangzhou Medical University, Guangzhou, Guangdong 511436, China
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CHEN Jiaxin1CHEN Jiaxin
Biomedical Research Center, Basic Medical School, Guangzhou Medical University, Guangzhou, Guangdong 511436, China
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TAN Xiao1TAN Xiao
Biomedical Research Center, Basic Medical School, Guangzhou Medical University, Guangzhou, Guangdong 511436, China
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YU Hongjiao2YU Hongjiao
Department of Biochemistry and Molecular Biology, School of Life Sciences, Guangzhou Medical University, Guangzhou, Guangdong 511436, China
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GAO Jun3GAO Jun
The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan, Guangdong 511518, China
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ZHU Dongxing1ZHU Dongxing
Biomedical Research Center, Basic Medical School, Guangzhou Medical University, Guangzhou, Guangdong 511436, China
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Affiliation:1.Biomedical Research Center, Basic Medical School, Guangzhou Medical University, Guangzhou, Guangdong 511436, China;2.Department of Biochemistry and Molecular Biology, School of Life Sciences, Guangzhou Medical University, Guangzhou, Guangdong 511436, China;3.The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan, Guangdong 511518, China)
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Abstract:

Vascular calcification is a common clinical complication in patients with chronic kidney disease, diabetes, hypertension and atherosclerosis. It is a significant risk factor for future cardiovascular events in these patients. There are currently no effective medications to slow or reverse the progression of vascular calcification. It has been previously reported that vascular calcification is an actively cellular-mediated pathological process, which shares many similarities to that of bone formation and bone metabolisms. The osteogenic transition of vascular smooth muscle cells plays an important role in vascular calcification. Recently, epigenetic regulators have emerged as key mediators of vascular calcification. This review summarizes our current understanding of epigenetic regulators such as DNA methylation, histone modification and non-coding RNAs in the pathogenesis of vascular calcification. Targeting epigenetic regulators may represent a novel strategy to treat vascular calcification.

Key words:vascular calcification; epigenetic regulation; vascular smooth muscle cells; osteogenic transition

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ZHONG Hui, WANG Suying, LI Daiying, CHEN Jieyi, CHEN Jiaxin, TAN Xiao, YU Hongjiao, GAO Jun, ZHU Dongxing. Epigenetic regulation of vascular calcification[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2021,29(10):838-844.

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Received:May 11,2021
Revised:July 06,2021
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Online: October 13,2021
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