Predictive value of serum PGC-1α mRNA and irisin levels on hemorrhagic transformation in patients with acute ischemic stroke
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1.Department of Geriatrics, the Third Hospital of Changsha, Changsha, Hunan 410015, China;2.Department of Neurology, Hunan Provincial People's Hospital, Changsha, Hunan 410016, China)

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R741

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    Abstract:

    Aim To investigate the predictive value of levels of serum peroxisome proliferator activated receptor γ coactivator-1α (PGC-1α) mRNA and irisin in patients with acute ischemic stroke. Methods 161 patients with acute ischemic stroke were divided into non secondary hemorrhagic transformation (HT) group (97 cases) and secondary HT group (64 cases) according to the presence or absence of secondary HT. The levels of PGC-1α mRNA and irisin in serum were detected by real-time quantitative PCR (qRT-PCR) and enzyme-linked immunosorbent assay (ELISA) respectively; Triglyceride (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDLC), high density lipoprotein cholesterol (HDLC) and creatinine were detected by automatic biochemical analyzer. The correlation between serum PGC-1α mRNA, irisin levels and blood lipids in patients with secondary HT to acute ischemic stroke was analyzed, the predictive value of serum PGC-1α mRNA and irisin levels was analyzed by receiver operating characteristic (ROC) curve, and the influencing risk factors were explored. Results The levels of PGC-1α mRNA, irisin and TG were lower in secondary HT group than those in non secondary HT group, while the level of HDLC in secondary HT group was higher than that in non secondary HT group (P<0.05); The serum PGC-1α mRNA and irisin of acute ischemic stroke patients with secondary HT were positively correlated with TG level (P<0.05), and negatively correlated with HDLC level (P<0.05); The area under the curve (AUC) of serum PGC-1α mRNA and irisin levels in predicting secondary HT in patients with acute ischemic stroke was 0.865 and 0.893, the specificity was 85.9% and 87.5%, and the sensitivity was 74.2% and 82.5%, respectively; The AUC of the combined diagnosis was 0.960, the specificity was 89.1%, and the sensitivity was 87.6%; In addition, PGC-1α mRNA and irisin were protective factors of secondary HT in patients with acute ischemic stroke (P<0.05), and HDLC was an independent risk factor (P<0.05). Conclusion The levels of serum PGC-1α mRNA and irisin in patients with secondary HT are significantly lower than those without HT, which may be of great value in predicting the occurrence of HT.

    Reference
    [1] 喻长莉, 李建军.急性缺血性脑卒中患者血清TIGAR mRNA水平及其与预后的关系.中国动脉硬化杂志, 0,8(7):589-593.
    [2] 张景忠, 齐英杰, 陈宇, 等.急性缺血性脑卒中局部VLCBV与DWI及ADC在预测出血转化中的对比研究.卒中与神经疾病, 9,6(2):165-8,7.
    [3] LI L, XIAO L, HOU Y, et al.Sestrin2 silencing exacerbates cerebral ischemia/reperfusion injury by decreasing mitochondrial biogenesis through the AMPK/PGC-1α pathway in rats.Sci Rep, 6,6(1):30272.
    [4] 王姝琪, 王晓峰.鸢尾素临床应用研究进展.中国现代医学杂志, 1,1(7):50-53.
    [5] 中华医学会神经病学分会脑血管病学组急性缺血性脑卒中诊治指南撰写组.中国急性缺血性脑卒中诊治指南2010.中华医学信息导报, 0,5(14):16-19.
    [6] 李鑫, 李琼莉, 王军伟, 等.急性缺血性脑卒中静脉溶栓后出血转化的多因素联合预测模型研究.中华老年心脑血管病杂志, 1,3(4):430-432.
    [7] 周帆, 黄云峰.血栓弹力图在急性脑梗死患者早期神经功能缺损及出血性转化风险性评估中的价值.实用临床医药杂志, 9,3(6):73-76.
    [8] LEE J, SALAZAR H M, AUEN T, et al.PGC-1α functions as a co-suppressor of XBP1s to regulate glucose metabolism.Mol Metab, 8,7(1):119-131.
    [9] WANG Y, RUAN W, MI J, et al.Balasubramide derivative 3C modulates microglia activation via CaMKKβ-dependent AMPK/PGC-1α pathway in neuroinflammatory conditions.Brain Behav Immun, 8,7(1):101-117.
    [10] ZHOU Y, WANG S, LI Y, et al.SIRT1/PGC-1α signaling promotes mitochondrial functional recovery and reduces apoptosis after intracerebral hemorrhage in rats.Front Mol Neurosci, 7,0(1):443.
    [11] 程启慧, 余丹, 杨国帅, 等.血清TN-C和Irisin在H型高血压合并急性缺血性脑卒中患者中的临床意义.天津医药, 9,7(8):828-832.
    [12] SEPP S, TENHOLA S, VOUTILAINEN R.Fibroblast growth factor 21, adiponectin, and irisin as markers of unfavorable metabolic features in 12-year-old children.J Endocr Soc, 9,3(4):825-837.
    [13] 张怡, 孙易, 丁树哲.新的肌肉因子——鸢尾素.中国生物化学与分子生物学报, 7,3(5):429-435.
    [14] 黄一伟.血清Irisin在急性缺血性脑卒中患者预后评估中的临床价值.中国全科医学, 9,2(s1):85-88.
    [15] TU W J, QIU H C, QIANG L, et al.Decreased level of irisin, a skeletal muscle cell-derived myokine, is associated with post-stroke depression in the ischemic stroke population.J Neuroinflammation, 8,5(1):133-178.
    [16] 关静.TG/HDL-C比值在急性缺血性脑卒中疾病中的应用及相关性研究.国际医药卫生导报, 0,6(16):2435-2438.
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YAO Liping, XIANG Jinhua, FU Li, YANG Qiming. Predictive value of serum PGC-1α mRNA and irisin levels on hemorrhagic transformation in patients with acute ischemic stroke[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2021,29(11):960-964.

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History
  • Received:September 25,2020
  • Revised:June 08,2021
  • Online: November 18,2021
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