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Research progress of Betatrophin lipid regulation
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1.Heart Center of the First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang Uygur Autonomous Region 830054, China;2.Department of Cardiology, The First Affiliated Hospital of Shihezi University School of Medicine, Shihezi, Xinjiang Uygur Autonomous Region 832008, China)

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R5

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    Abstract:

    Betatrophin, also known as lipasin or angiopoietin-like protein 8 (ANGP TL8), is mainly expressed in human liver and adipose tissue. There is increasing evidence to show the correlation between betatrophin expression and blood lipid levels, and especially in patients of obesity or diabetes, stimulated by factors such as insulin, thyroid hormone, and energy intake, it can lead to an increase in betatrophin levels. It has also been verified in animal models that betatrophin can increase serum triglyceride levels and promote the proliferation of pancreatic β-cells. This article reviews the latest research progress of betatrophin in lipid regulation.

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QIN Lian, MA Xiang, WANG Zhong, DU Yiying, ZHANG Dan. Research progress of Betatrophin lipid regulation[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2021,29(12):1085-1088.

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History
  • Received:August 12,2020
  • Revised:July 26,2021
  • Online: November 24,2021
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