The low density lipoprotein receptor-related protein 6 (LRP6) is one of the important receptor proteins that perform the canonical Wnt/β-catenin pathway. Mutations in the protein are often associated with a variety of human diseases, including metabolic syndrome, tumor, Alzheimer's disease and osteoporosis. The mutation of low-density lipoprotein receptor-related protein 6 will have important guiding significance in the clinical diagnosis. In this paper, the function of low-density lipoprotein receptor-related protein 6 and the occurrence and development of related diseases will be summarized to provide useful resources for future research.