Cardiovascular disease is the number one disease threatening human health. Myocardial infarction usually has an acute onset and high mortality, which brings a huge burden to patients and their families. How to reduce myocardial cell death is the main way to treat myocardial infarction. Although coronary intervention can reconstruct coronary blood flow after myocardial infarction, ischemia-reperfusion injury caused by revascularization will also damage cardiomyocytes and lead to cardiomyocyte death. Hippo signaling pathway has many functions, including promoting cell proliferation and regulating cell apoptosis. Therefore, whether Hippo signaling pathway can promote cardiomyocyte proliferation, reduce cardiomyocyte apoptosis and improve cardiac function in patients with myocardial infarction has become a research hotspot. This paper reviews the role and research progress of Hippo signaling pathway in myocardial infarction, so as to provide new ideas for clinical treatment of myocardial infarction.