The roles of Hippo signaling pathway in myocardial infarction and its research progress

Home > Archive>Volume 30, Issue 2, 2022 >175-179

The roles of Hippo signaling pathway in myocardial infarction and its research progress
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                        CHAI Aomin1,2CHAI Aomin
Department of General Practice, Shenzhen, Guangdong 518035, China ;Shenzhen Luohu Hospital Group, Shenzhen, Guangdong 518001, China
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YANG Jingjing3YANG Jingjing
Department of Internal Medicine, Guangdong Provincial Peoples Hospital, Guangzhou, Guangdong 510080, China
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LIAO Haihan4LIAO Haihan
Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, China
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FENG Yongwen5FENG Yongwen
Department of Critical Care Medicine, Shenzhen Second Peoples Hospital Affiliated to Guangzhou Medical University, Shenzhen, Guangdong 518035, China
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Affiliation:1.Department of General Practice, Shenzhen, Guangdong 518035, China ;5.Department of Critical Care Medicine, Shenzhen Second People's Hospital Affiliated to Guangzhou Medical University, Shenzhen, Guangdong 518035, China;2.Shenzhen Luohu Hospital Group, Shenzhen, Guangdong 518001, China;3.Department of Internal Medicine, Guangdong Provincial People's Hospital, Guangzhou, Guangdong 510080, China;4.Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, China)
Clc Number:R54
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Abstract:

Cardiovascular disease is the number one disease threatening human health. Myocardial infarction usually has an acute onset and high mortality, which brings a huge burden to patients and their families. How to reduce myocardial cell death is the main way to treat myocardial infarction. Although coronary intervention can reconstruct coronary blood flow after myocardial infarction, ischemia-reperfusion injury caused by revascularization will also damage cardiomyocytes and lead to cardiomyocyte death. Hippo signaling pathway has many functions, including promoting cell proliferation and regulating cell apoptosis. Therefore, whether Hippo signaling pathway can promote cardiomyocyte proliferation, reduce cardiomyocyte apoptosis and improve cardiac function in patients with myocardial infarction has become a research hotspot. This paper reviews the role and research progress of Hippo signaling pathway in myocardial infarction, so as to provide new ideas for clinical treatment of myocardial infarction.

Key words:Hippo signaling pathway; myocardial infarction; cardiomyocyte

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CHAI Aomin, YANG Jingjing, LIAO Haihan, FENG Yongwen. The roles of Hippo signaling pathway in myocardial infarction and its research progress[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2022,30(2):175-179.

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Received:November 07,2020
Revised:January 10,2021
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Online: January 07,2022
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