N6-methyladenine regulates mitochondrial function and its research progress in metabolic diseases

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N6-methyladenine regulates mitochondrial function and its research progress in metabolic diseases
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                        YANG Min1,2YANG Min
Institute of Translational Medicine, Hengyang Medical College, University of South China, Hengyang, Hunan 421001, China;Guangxi Key Laboratory of Diabetic Systems Medicine, Guilin Medical University, Guilin, Guangxi 541100, China
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LIU Jiaqi2LIU Jiaqi
Guangxi Key Laboratory of Diabetic Systems Medicine, Guilin Medical University, Guilin, Guangxi 541100, China
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ZHU Xiao2ZHU Xiao
Guangxi Key Laboratory of Diabetic Systems Medicine, Guilin Medical University, Guilin, Guangxi 541100, China
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JIANG Xiaping2JIANG Xiaping
Guangxi Key Laboratory of Diabetic Systems Medicine, Guilin Medical University, Guilin, Guangxi 541100, China
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YANG Siqi1YANG Siqi
Institute of Translational Medicine, Hengyang Medical College, University of South China, Hengyang, Hunan 421001, China
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YIN Kai2YIN Kai
Guangxi Key Laboratory of Diabetic Systems Medicine, Guilin Medical University, Guilin, Guangxi 541100, China
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GUI Qingjun1GUI Qingjun
Institute of Translational Medicine, Hengyang Medical College, University of South China, Hengyang, Hunan 421001, China
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Affiliation:1.Institute of Translational Medicine, Hengyang Medical College, University of South China, Hengyang, Hunan 421001, China;2.Guangxi Key Laboratory of Diabetic Systems Medicine, Guilin Medical University, Guilin, Guangxi 541100, China)
Clc Number:R365；R5
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Abstract:

N6-methyladenine (6mA) is an epigenetic modification existed in eukaryotes, which dynamically regulates transcription by modifying mitochondrial DNA, non-coding genes and ribosomal DNA. Current studies have found that 6mA affects mitochondrial activity and function by regulating mitochondrial DNA transcription, etc., and then participates in the occurrence and development of metabolic diseases. This paper discusses the mechanism of 6mA regulating mitochondrial function and its role in metabolic diseases such as obesity, atherosclerosis, hypertension and cancer, which is expected to provide new ideas for the prevention and treatment of metabolic-related diseases.

Key words:N6-methyladenine; mitochondrial function; metabolic disease

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YANG Min, LIU Jiaqi, ZHU Xiao, JIANG Xiaping, YANG Siqi, YIN Kai, GUI Qingjun. N6-methyladenine regulates mitochondrial function and its research progress in metabolic diseases[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2022,30(5):442-448.

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Received:December 26,2021
Revised:March 25,2022
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Online: May 10,2022
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