Aim To explore the predictive value of peripheral blood angiotensinⅡ (AngⅡ), ischemia-modified albumin (IMA) and C-reactive protein (CRP) for venous thromboembolism (VTE). Methods 170 patients with VTE who were treated in Shijiazhuang People's Hospital from June 2018 to January 2021 were selected as the study group, and 101 healthy subjects in the same period were selected as the control group. The levels of AngⅡ, IMA and CRP in the two groups were detected in strict accordance with the instructions of ELISA kit. Logistic regression analysis was used to analyze the correlation between AngⅡ, IMA and CRP and VTE. Results The levels of AngⅡ, IMA and CRP in the study group were significantly higher than those in the control group, and the level of D-dimer in the study group was significantly lower than that in the control group (P＜0.05). There was no significant difference in HDL, LDL and platelet count between the two groups (P＞0.05). The levels of triglyceride and fibrinogen in the study group were significantly higher than those in the control group (P＜0.05). Logistic regression analysis showed that AngⅡ, IMA and CRP were independent risk factors for VTE. In the ROC curve, the sensitivity and specificity of AngⅡ, IMA and CRP were 97.6% and 88.9% respectively. Conclusion The three indexes of AngⅡ, IMA and CRP in peripheral blood have good value in the prediction of VTE and are worthy of further promotion in clinic.