Ferroptosis is a novel form of programmed cell death, characterized by intracellular iron overload-induced production of lipid peroxides and massive accumulation in cells leading to cell death. Heart failure is a serious cardiac dysfunction, and the reduction of cardiomyocytes is the main reason for its occurrence and development. Recent studies have shown that ferroptosis occurs in heart failure and confirmed that ferroptosis plays a crucial role in its pathogenesis. This article intends to review the mechanism of ferroptosis and its impact on heart failure.