Coronary artery calcification is commonly seen in patients with coronary atherosclerotic heart disease, but the mechanism of its happening, development, and formation is less known. Gla-rich protein (GRP) is a newly discovered vitamin K-dependent protein. Studies have shown that GRP inhibits the formation and maturation of calcified crystals by binding to minerals, participates in the inhibition pathway of matrix Gla protein-fetuin-A calcification, blocks the signalling pathway of calcification inducers and has an anti-inflammatory effect, thus playing a role in inhibiting vascular calcification. In this paper, the research progress of GRP's participation in the mechanism of coronary artery calcification will be conducted in the hope of providing a new direction for the prevention and treatment of coronary artery calcification.