The role of ferroptosis in the pathogenesis of hypertension
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1.Changsha Central Hospital Afiliated to University of South China, Changsha, Hunan 410004, China;2.Institute of Cardiovascular Disease, University of South China & Key Laboratory for Arteriosclerology of Hunan Province & Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic Disease, Hengyang, Hunan 421001, China)

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R5

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    Abstract:

    Ferroptosis is a newly discovered iron-dependent mode of programmed cell death, characterized by intracellular iron overload, glutathione depletion and lipid peroxidation. Hypertension is one of the important risk factors for the occurrence of cardiovascular and cerebrovascular diseases, and more and more studies have shown that hypertension is closely related to ferroptosis. This article will review the association between ferroptosis and hypertension, as well as the possible mechanisms of ferroptosis affecting hypertension, in order to provide new ideas for the treatment of hypertension.

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GAN Ni, CUI Yuting, ZHOU Yating, XIANG Qiong, PENG Juan, TANG Zhihan. The role of ferroptosis in the pathogenesis of hypertension[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2023,31(5):441-448.

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History
  • Received:January 04,2023
  • Revised:March 09,2023
  • Adopted:
  • Online: May 19,2023
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