Ferroptosis:a new target for the prevention and treatment of abdominal aortic aneurysm?
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Institute of Cardiovascular Disease, University of South China & Key Laboratory for Arteriosclerology of Hunan Province & Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic Disease, Hengyang, Hunan 421001, China)

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R363;R5

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    Abstract:

    Ferroptosis is an iron-dependent, non-apoptotic programmed cell death characterized by iron metabolism disorder that leads to intracellular iron overload, which induces lipid peroxidation through fenton reaction and activates ferroptosis. Ferroptosis is associated with many diseases, among which the relationship with abdominal aortic aneurysm has come into attention in the last few years. Abdominal aortic aneurysm is a degenerative disease characterized by structural destruction and irreversible dilation of the abdominal aortic wall. Its pathogenesis is related to oxidative stress, inflammation, loss of vascular smooth muscle cells and vascular calcification. Ferroptosis may play a role in the development of abdominal aortic aneurysm through the above pathways. Therefore, this paper reviews the pathogenesis of ferroptosis and abdominal aortic aneurysm, providing a new idea and target for the abdominal aortic aneurysm treatment.

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ZHOU Yating, XIANG Qiong, LIAO Wei, XIA Mengdie, LIU Lushan, TANG Zhihan, PENG Juan. Ferroptosis:a new target for the prevention and treatment of abdominal aortic aneurysm?[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2023,31(6):527-532.

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History
  • Received:February 21,2023
  • Revised:March 18,2023
  • Adopted:
  • Online: June 12,2023
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