As one of the common diseases caused by atherosclerosis, coronary heart disease has various and complex pathogenesis. How to prevent and treat coronary heart disease has become a global hot health issue. Studies have found that among the risk factors for coronary heart disease, various oral diseases such as periodontitis, caused by oral microbiome disorders, can greatly increase the risk of coronary heart disease. In order to explore the correlation between coronary heart disease and oral microorganisms, this paper discusses the possible pathogenic mechanism of periodontitis caused by oral microorganisms on coronary heart disease, in order to provide new ideas and references for the prevention and treatment of coronary heart disease.