Targeting CD36 to regulate lipid metabolism:a new strategy for the prevention and treatment of diabetic cardiomyopathy

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Targeting CD36 to regulate lipid metabolism:a new strategy for the prevention and treatment of diabetic cardiomyopathy
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                        ZHOU Jiaqi1ZHOU Jiaqi
Department of Anesthesiology, Affiliated Hospital of Guangdong Medical University, Zhanjian, Guangdong 524000, China
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LIN Jiefu1LIN Jiefu
Department of Anesthesiology, Affiliated Hospital of Guangdong Medical University, Zhanjian, Guangdong 524000, China
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CHEN Jiajia1CHEN Jiajia
Department of Anesthesiology, Affiliated Hospital of Guangdong Medical University, Zhanjian, Guangdong 524000, China
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XIE Lin1XIE Lin
Department of Anesthesiology, Affiliated Hospital of Guangdong Medical University, Zhanjian, Guangdong 524000, China
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XIA Zhengyuan1,2,3XIA Zhengyuan
Department of Anesthesiology, Affiliated Hospital of Guangdong Medical University, Zhanjian, Guangdong 524000, China;State Key Laboratory of Pharmaceutical Biotechnology, Department of Medicine, University of Hong Kong, Hong Kong 999077, China;Doctoral Training Platform for Research and Translation, Boshiwan, Guanchong Village, Zhongxiang, Hubei 431900, China
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Affiliation:1.Department of Anesthesiology, Affiliated Hospital of Guangdong Medical University, Zhanjian, Guangdong 524000, China;2.State Key Laboratory of Pharmaceutical Biotechnology, Department of Medicine, University of Hong Kong, Hong Kong 999077, China;3.Doctoral Training Platform for Research and Translation, Boshiwan, Guanchong Village, Zhongxiang, Hubei 431900, China)
Clc Number:R5；R363
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Abstract:

Abnormalities in lipid metabolism induce myocardial structural and functional disorders, leading to the development of diabetic cardiomyopathy (DCM), which has become a hotspot in current DCM research. The transmembrane glycoprotein CD36 is a multifunctional membrane protein that facilitates fatty acid transport, which is involved in the regulation of cardiac lipid metabolism. CD36 signaling plays a key role in the pathogenesis of DCM mediated cardiac injuries. This article summarizes the structure of CD36 and its role in specific cell types, and further explores the pathophysiological role of CD36 in DCM, proposing that targeting CD36 may prove to be a potential pharmacological strategy in the prevention and treatment of DCM.

Key words:CD36; diabetic cardiomyopathy; lipid metabolism; myocardial ischemia reperfusion injury

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ZHOU Jiaqi, LIN Jiefu, CHEN Jiajia, XIE Lin, XIA Zhengyuan. Targeting CD36 to regulate lipid metabolism:a new strategy for the prevention and treatment of diabetic cardiomyopathy[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2023,31(12):1013-1019.

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Received:November 16,2023
Revised:December 03,2023
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Online: December 29,2023
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